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Amyloid Precursor Protein APP基因表达质粒敲除载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

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  • 货  号:Amyloid Precursor Protein APP基因表达质粒敲除载体
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Amyloid Precursor Protein APP基因表达质粒敲除载体

Product Name  Amyloid Precursor Protein (APP) (NM_001136129) Human Tagged ORF Clone
Symbol  APP
Synonyms  AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4
ACCN  NM_001136129
ORF Size  1917 bp
RefSeq  NM_001136129.1, NM_001136129.2, NP_001129601.1
RefSeq ORF  1920
Locus ID  351
Cytogenetics  21q21.3
Protein Families  Druggable Genome, Transmembrane
Protein Pathways  Alzheimer's disease
MW  72.55 kDa
Gene Summary  This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene

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