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NP69 Human Nasopharyngeal Epithelial Cell Line人鼻咽癌上皮细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

  • 价  格:¥49865
  • 货  号:NP69 Human Nasopharyngeal Epithelial Cell Line人鼻咽癌上皮细胞株
  • 产  地:北京
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NP69 Human Nasopharyngeal Epithelial Cell Line人鼻咽癌上皮细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心
Description NP69 Human Nasopharyngeal Epithelial Cell Line
Overview The NP69 immortalized human nasopharyngeal epithelial cell line retains many of the characteristics of normal nasopharyngeal cells, including keratin profiles and response to TGF-beta, while possessing many of the genetic signatures observed in NPC (2). NP69 cells are non-tumorigenic and demonstrate anchorage-dependent growth (2). The NP69 cell line is particularly useful for studies of the mechanisms of viral-associated tumorigenesis.

Source:
NP69 cells were derived from passage 1 cultures of biopsy-isolated primary nasopharyngeal epithelial cells transfected with the PX8 plasmid containing the simian virus 40 large T antigen (1).
Alternate Names • NP69SV40T
• NP-69
Background Information Nasopharyngeal carcinoma (NPC), the most common cancer arising in the nasopharyngeal region, arises from epithelial cells and is especially prevalent in areas of southeast Asia and as a childhood cancer in some African populations (1). NPC ontology and tumorigenesis is closely associated with viral factors, especially Epstein-Barr virus (EBV) and human papillomavirus (HPV) (1).

References:
1. Lancet 2016; 387(10022): 1012-1024.
2. Biochim Biophys Acta 2002; 1590(1-3): 150-158.
Applications
Application The NP69 cell line is useful for studies of the mechanisms of viral-associated tumorigenesis

Quality Assurance • Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.

【Supplier来源】BioVector NTCC Inc.
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