pcDNA3.1-IGF-1 plasmid vector质粒载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

pcDNA3.1-IGF-1 plasmid vector质粒载体

RefSeq NM_000875.1, NM_000875.2, NM_000875.3, NM_000875.4, NP_000866.1 RefSeq Size 4989 bp RefSeq ORF 4104 bp Locus ID 3480 Cytogenetics 15q26.3 Protein Families Druggable Genome, Protein Kinase, Transmembrane Protein Pathways Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer MW 154.79 kDa Gene Summary This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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