capan-1（KRAS依赖）cell line细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

capan-1（KRAS依赖）cell line细胞株

Cell line name Capan-1
Synonyms CaPan-1; CAPAN-1; Capan 1; CAPAN 1; Capan1; CAPAN1
Accession CVCL_0237
Resource Identification Initiative To cite this cell line use: Capan-1 (RRID:CVCL_0237)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI RAS program mutant KRAS cell line panel.
Part of: TCGA-110-CL cell line panel.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 923.
Doubling time: 60-80 hours (CLS); ~50-100 hours (DSMZ); ~49 hours (PBCF).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: CANPAN-1; In Cosmic 2434105.
Sequence variations Mutation; HGNC; 1101; BRCA2; Simple; p.Ser1982Argfs*22 (c.5946delT) (6174delT); ClinVar=VCV000009325; Zygosity=Hemizygous (PubMed=8968085; PubMed=21750719; CCLE; Cosmic-CLP).
Mutation; HGNC; 4039; FZD10; Simple; p.Asn54Lys (c.162C>A); Zygosity=Homozygous (PubMed=21750719; CCLE; Cosmic-CLP).
Mutation; HGNC; 23671; GLT6D1; Simple; p.Trp198Ter (c.593G>A); Zygosity=Heterozygous (PubMed=21750719; CCLE; Cosmic-CLP).
Mutation; HGNC; 4593; GRM1; Simple; p.Tyr486Ter (c.1458C>A); Zygosity=Homozygous (PubMed=21750719; CCLE; Cosmic-CLP).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (PubMed=8026879; PubMed=8426738; PubMed=15367885; PubMed=21750719; CCLE; Cosmic-CLP).
Mutation; HGNC; 6844; MAP2K4; Simple; p.Glu221Ter (c.661G>T); Zygosity=Homozygous (PubMed=9331070; PubMed=21750719; CCLE; Cosmic-CLP).
Mutation; HGNC; 6770; SMAD4; Simple; p.Ser343Ter (c.1028C>G); Zygosity=Homozygous (PubMed=10408907; PubMed=21750719; CCLE; Cosmic-CLP).
Mutation; HGNC; 25082; SMAP2; Simple; p.Ser255Ter (c.764C>G); Zygosity=Heterozygous (PubMed=21750719; CCLE; Cosmic-CLP).
Mutation; HGNC; 11998; TP53; Simple; p.Ala159Val (c.476C>T); ClinVar=VCV000458545; Zygosity=Homozygous (PubMed=8026879; PubMed=8426738; PubMed=15367885; CCLE; Cosmic-CLP).
HLA typing Source: CLS
Class I
HLA-A A*02,09
HLA-B B*13,17
Genome ancestry Source: PubMed=30894373

Origin % genome
African 1.95
Native American 0.56
East Asian, North 4.79
East Asian, South 0.11
South Asian 7.09
European, North 19.06
European, South 66.44
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_S022 (Capan-1 SimpleCell O-GalNAc) CVCL_0A59 (Capan1M9)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line

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