Bacteroides fragilis bft-3 strain菌株 BioVector NTCC质粒载体菌种细胞基因保藏中心
- 价 格:¥989865
- 货 号:Bacteroides fragilis bft-3
- 产 地:北京
- BioVector NTCC典型培养物保藏中心
- 联系人:Dr.Xu, Biovector NTCC Inc.
电话:400-800-2947 工作QQ:1843439339 (微信同号)
邮件:Biovector@163.com
手机:18901268599
地址:北京
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Bacteroides fragilis bft-3 strain菌株
ETBF strains have a conjugative transposon containing a pathogenicity island with a distinct virulence gene encoding a 20-kDa metalloprotease toxin called the B. fragilis toxin or BFT (also known as fragilysin). BFT is secreted and is detectable in stool. Three subtypes of BFT (BFT-1, BFT-2 and BFT-3) have been identified, with BFT-1 expressed by about two-thirds of ETBF isolated around the globe followed by BFT-2 (25%) and BFT-3 (~10% and mostly identified in South-east Asia). BFT stimulates the cleavage of intercellular adhesion protein E-cadherin on colonic epithelial cells, resulting in increased human colon permeability and activates nuclear factor-kappa B signalling, resulting in proinflammatory cytokine secretion by colonic epithelial cells.
Supplier来源:BioVector NTCC Inc.
TEL电话:400-800-2947
Website网址: http://www.biovector.net
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