PV-SARS-CoV-2-S-VSV-△G-EGFP plasmid vector质粒载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

PV-SARS-CoV-2-S-VSV-△G-EGFP plasmid vector质粒载体

Pseudotyped BioVector® VSV-SARS-CoV-2 S-ΔG-GFP encodes the antigenomic-sense (or positive-sense) RNA of a replicaton-restricted recombinant vesicular stomatitis virus (rVSV) in which the glycoprotein (G) gene has been replaced with SARS-CoV-2 spike protein. Because the infectivity of Pseudotyped VSV-SARS-CoV-2 S-ΔG-GFP is restricted to a single round of replication, the pseudotypes can be handled using BSL-2 containment practices. The pseudotype VSV particles encode GFP together with the VSV nucleocapsid (N), phosphoprotein (P), glycoprotein (G), and large polymerase subunit (L) in their pVSV-ΔG vector. When the VSV pseudovirus infect the target cells, GFP expression is proportional to the number of cells that were infected.

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