8E5 cell line儿童T细胞急性淋巴母细胞白血病细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

8E5 cell line儿童T细胞急性淋巴母细胞白血病细胞株

Cell line name 8E5
Synonyms 8E5(CEM); 8E5/LAV

Comments Group: Patented cell line.
Population: Caucasian.
Characteristics: HIV-1 producing cell line.
Derived from sampling site: Peripheral blood.

Sequence variations
Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).

Disease Childhood T acute lymphoblastic leukemia
Precursor T-cell acute lymphoblastic leukemia
Species of origin Homo sapiens (Human)

Hierarchy Parent: (CEM A3.01)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line

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