FXR核激素受体稳定表达细胞株NTCC® Nuclear Hormone Receptor Stable Cell Line-FXR药物靶点-BioVector NTCC细胞库

Cell Line Name：NTCC® FXR核激素受体稳定表达细胞株NTCC® Nuclear Hormone Receptor Stable Cell Line

Target药物靶点：FXR
Cat#货号:NTCC®-N-FXR
Size/Quantity数量: 1 Flask / 2 Vials
Biosafety Level生物安全级别: 1
Shipping Info运输方式: RT/Dry Ice
Storage储存方式: RT/Liquid Nitrogen
Application用途:Protein Interaction
Nuclear proteins are key targets for drug development due to their ubiquitous roles in controlling cellular behavior and pathway expression. The translocation of many nuclear proteins into and out of the nucleus is a highly controlled mechanism that can dictate protein function. Controlling this translocation behavior using therapeutics, or ensuring that a potential drug does not cause undesired effects on translocation, are important applications for measuring nuclear translocation. Nuclear hormone receptors (NHRs), including steroid receptors, are a critical subset of nuclear proteins that regulate gene expression in response to ligand activation and are intimately involved in endocrine pathway signaling. NHRs commonly rely on a coactivator or corepressor protein, often a steroid receptor cofactor (SRC protein), to perform their function. Enhancing or disrupting the association of these proteins can be a target for therapeutic development focused on controlling NHR-related gene expression. BioVector NTCC Inc. provides NTCC®PathHunter nuclear translocation and protein interaction cell-based, functional assays to investigate protein translocation events and activation of nuclear proteins. Nuclear translocation assays allow for studying the trafficking of your protein of interest to and from the nucleus and analyzing the pharmacological effects of therapeutics on these events. Protein interaction assays can be used to evaluate the interaction of NHRs and their cofactors, including therapeutics that affect this protein-protein interaction. 核受体（NHR）作为药物靶点 核受体（NHR）是配体激活转录因子，参与重要的生理过程，如癌症、糖尿病、类风湿性关节炎、哮喘或激素抵抗综合征。因此，核激素受体在现代生物医学研究和药物开发中具有重大意义。 核激素受体（NHR）是一种可溶性蛋白质，可以通过与特定DNA序列相互作用来调节基因表达，使治疗药物能在转录水平上作用于特定靶点。 与其他转录因子相反，核受体可以通过结合到相应的配体来调节活性，小的亲脂性分子能轻易地穿透生物膜。最近几年中确定的一些核受体不具有任何已知的配体。这些所谓的孤儿受体自从它们可能导致新的内分泌调节系统的发现已吸引很多人相当大的兴趣。
Cell Line: ．
EXpress Kit:
Bioassay Kit生物检测试剂盒:
Protein蛋白:
Cell Type细胞类型: Nuclear Hormone Receptor Stable Cell Line
Source组织来源:
Specification规格:
Cell Images细胞图片:
Complete Growth Medium完全培养基: NTCC® FXR Stable Cells Complete Medium
Subculturing传代方法:
Cryopreservation冻存方法:Freeze medium: Complete growth medium supplemented with 5% (v/v) DMSO
Storage temperature: RT/Liquid nitrogen vapor phase
Culture Conditions培养条件:Atmosphere: air, 95%; carbon dioxide (CO2), 5%
Temperature: 37.0°C
STR Profile鉴定数据:
References参考文献:

Supplier供应商:
BioVector质粒载体菌株细胞蛋白抗体基因保藏中心
NTCC典型培养物保藏中心
Tel电话：400-800-2947
Email：Biovector@163.com
http://www.biovector.net