OVCAR-4 NTCC®高级别浆液性人卵巢腺癌细胞株-BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

OVCAR-4 NTCC®高级别浆液性人卵巢腺癌细胞株-BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

OVCAR-4 cells are a crucial model system in ovarian cancer research, representing a significant challenge due to their inherent chemoresistance.

OVCAR4 cells

Key characteristics:

• Origin: Derived from a patient with advanced ovarian cancer refractory to cisplatin treatment.

• Histological type: High-grade serous ovarian adenocarcinoma.

• Chemoresistance: Resistant to multiple chemotherapeutic agents, including cisplatin, doxorubicin, and paclitaxel.

• Tumorigenic: Can form tumors in animal models.

• Genetic alterations: Homozygous for a mutation in the TP53 gene and expresses high levels of the integrin αvβ3, a marker associated with tumor aggressiveness and drug resistance.

Research applications:

• Ovarian cancer biology: Understanding the mechanisms of chemoresistance in ovarian cancer.

• Drug discovery: Screening for new anticancer drugs that can overcome chemoresistance.

• Gene therapy: Developing targeted therapies for ovarian cancer.

Significance in research:

OVCAR-4 cells provide a valuable model for studying chemoresistant ovarian cancer. By understanding the mechanisms of drug resistance in these cells, researchers can develop more effective therapies for patients with this challenging disease.

生产厂家Supplier:

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

E-mail:BioVector@163.com

http://www.biovector.net