合胞病毒抗原 BioVector® NTCC典型培养物保藏中心

呼吸道合胞病毒抗原 Recombinant RSV F0 （His Tag）
Source：

Human respiratory syncytial virus A (strain A2)

Cat.No.:

A00901

Tag:

His Tag

Molecular Mass：

55.63 kDa

Expression Host：

HEK293 cells

Formulation：

Purified, Liquid

Buffer：

Phosphate Buffered Saline,5%mannital,0.05% Tween20, pH7.4

Purification：

>95% pure (SDS-PAGE).

Storage:

For long term storage, the product should be stored at -20°C or lower.



Please avoid repeated freeze-thaw cycles.







Description：

Respiratory syncytial virus (RSV) is a filamentous enveloped, negative-sense, single-stranded RNA virus. The RSV genome is 15.2 kb and contains 10 genes encoding 11 proteins. The M2 gene has two overlapping ORFs, generating both M2-1 (a transcription processivity factor) and M2-2 (a protein that governs the switch from transcription to genome replication). The first two transcribed genes are the nonstructural proteins NS1 and NS2, which together inhibit apoptosis and interferon responses.The RSV virion contains a lipid bilayer displaying the fusion (F), attachment (G) and small hydrophobic (SH) proteins. The F and G proteins are in greater abundance than the SH protein, which is a pentameric ion channel thought to be involved in delaying apoptosis in infected cells. The viral envelope is supported by a layer of matrix (M) and M2-1 proteins. The M protein is a non-glycosylated structural protein lining the inner leaflet of the viral envelope, and it associates with the cytoplasmic domain of the F protein. M2-1 mediates the association between M and the enclosed ribonucleoprotein complexes (RNPs) comprising viral genomic RNA tightly associated with nucleoprotein (N). Also associated with the RNP is the RNA-dependent RNA polymerase complex (RdRp) composed of the large polymerase subunit (L), a phosphoprotein polymerase cofactor (P) and N.







图1 呼吸道合胞病毒的结构









图2 呼吸道合胞病毒的复制过程











参考文献：
[1] Battles MB, McLellan JS. 2019. Nat Rev Microbiol. 17(4):233-245.
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