GIST882 NTCC®人胃肠道间质瘤细胞株human Gastrointestinal Stromal Tumor cell line BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

GIST882 NTCC®人胃肠道间质瘤细胞株human Gastrointestinal Stromal Tumor cell line

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

• GIST882 is a human cell line derived from a Gastrointestinal Stromal Tumor (GIST).

• Key Features:

  • Origin: GISTs are rare tumors that arise from the gastrointestinal tract.

  • Genetic Alterations: GIST882 cells typically harbor mutations in the KIT or PDGFRA genes, which are crucial for cell growth and survival. These mutations are common in GISTs.

  • Research Applications:

    • GIST Research: Used to study the biology of GISTs, including tumor growth, invasion, and metastasis.

    • Drug Discovery: Employed to screen for and evaluate new drugs for the treatment of GISTs, particularly those targeting KIT or PDGFRA signaling pathways.

    • Understanding Tumor Biology: Investigating cellular mechanisms involved in tumor development and progression.

    
    

  
  

Significance in Research:

• GIST882 cells provide a valuable in vitro model for studying GISTs and developing targeted therapies.

• The presence of specific genetic alterations in these cells allows researchers to investigate the effects of these mutations on tumor behavior.

• Research using GIST882 cells contributes to a better understanding of GIST pathogenesis and the development of more effective treatment strategies.

Note:

• The use of GIST882 cells requires appropriate safety measures in the laboratory, as it involves working with human cell lines.

• The characteristics and behavior of GIST882 cells can be influenced by various factors, such as culture conditions and the presence of other cells or factors in the environment.

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