NTCC® HEK-293-hERG Cell Line人胚肾hERG基因稳定表达细胞株 BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

NTCC® HEK-293-hERG Cell Line人胚肾hERG基因稳定表达细胞株

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

HEK293hERG cell line

The HEK-293-hERG cell line is a genetically engineered cell line derived from human embryonic kidney cells (HEK-293). It is widely used in scientific research, particularly in the field of cardiology, to study the human ether-a-go-go-related gene (hERG) potassium channel.

hERG Potassium Channel

The hERG potassium channel plays a crucial role in the repolarization phase of the cardiac action potential. It helps to regulate the heart's rhythm and contraction. Dysfunction of this channel can lead to serious heart conditions, including long QT syndrome, which can increase the risk of life-threatening arrhythmias.

HEK-293-hERG Cell Line Applications

The HEK-293-hERG cell line provides a valuable model system for studying the hERG channel and its role in cardiac function. It is used for various research purposes, including:

• Drug screening: To identify potential drugs that may affect the hERG channel and cause cardiac side effects.

• Basic research: To investigate the molecular mechanisms underlying hERG channel function and regulation.

• Disease modeling: To study the effects of genetic mutations associated with long QT syndrome on hERG channel activity.

Key Features of HEK-293-hERG Cell Line

• Stable expression of hERG channel: The cell line consistently expresses high levels of functional hERG channels.

• Ease of culture: HEK-293 cells are relatively easy to culture in vitro, making them suitable for high-throughput screening and other experimental applications.

• Well-characterized: The properties of the HEK-293-hERG cell line have been extensively studied, providing a reliable platform for research.

By utilizing the HEK-293-hERG cell line, scientists can gain valuable insights into the hERG channel and its role in cardiac health and disease. This knowledge can contribute to the development of safer and more effective drugs, as well as improved treatments for cardiac arrhythmias.

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